Evaluation of the Nephroprotective Effect of Omega-3 Polyunsaturated Fatty Acids on Gentamicin-Induced Renal Toxicity in Albino Wistar Rats
The kidney performs several important functions in the body. Its failure leads to a dysfunction that deserves a solution. Thus, this study was initiated to investigate the protective effects of omega-3 fatty acids on nephrotoxicity. For this purpose, 48 Albino Wistar rats (male and female) were divided into 8 groups of 6 rats. The first group, serving as a control, received 1 mL/g body weight of distilled water daily by gavage and a 0.9% NaCl solution intraperitoneally one hour later. The second, received gentamicin at a dose of 80 mg/Kg/day by intraperitoneal injection for 7 days, the third, treated with the combination of omega 3 by gavage at a dose of 200 mg/Kg of body weight plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for the same period. The fourth, treated with the combination of omega 3 by gavage at a dose of 600 mg/Kg body weight plus gentamycin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days, the fifth, treated with the combination of vitamin E at a dose of 250 mg/kg/day body weight by gavage plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days. The sixth and seventh received 200 mg/kg and 600 mg/kg body weight by gavage of omega-3 for 7 days, respectively. The last group received vitamin E at a dose of 250 mg/kg/day of body weight by gavage. Omega-3 at a dose of 600 mg/kg body weight exerts a protective effect against induced nephrotoxicity in rats (especially females), with a decrease in urea and creatinine levels. The consumption of food rich in omega 3 in the protection of the kidneys advised. Further studies could be envisaged to compare the protective effects of omega-3 with other polyunsaturated fatty acids (omega-6 and 9) on nephrotoxicity.
