Lipidomics Bioinformatics Analysis
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Abstract
Untargeted and targeted lipidomics are two categories of lipidomics that are often used in combination for the discovery and quantification of differential lipid molecules. Untargeted lipidomics uses LC-MS and GC-MS technologies to unbiasedly detect the dynamic changes of all lipid molecules before and after the stimulation or disturbance in cells, tissues, organs, or organisms. Through bioinformatics analysis to screen differential lipid molecules and analyze their pathways, untargeted lipidomics can reveal the physiological mechanism of their changes. Targeted lipidomics is the research and analysis of a specific class of lipids. Obtainingtedious data from this assay is not the end goal. Bioinformatics analysis can organize, mine, and visualize data, and thus extract useful biological information from large amounts of data to help with scientific discovery.
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