Vertigo And Dizziness Program PDF
Authors: Christian Goodman
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Diabetes Freedom PDF
Authors: George Reilly
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Some Aspects of Overturning Mechanisms of Pile Driving Machine on Soft Foundation
Authors: Shouji Toma , Wai Fah Chen
In Research
Many overturning accidents of cranes and pile driving machines have occurred in recent years. Overturning mechanisms of those accidents have been studied by the author, et al., based on theory of structural stability by using the rotational spring-rigid bar model. A summary of the theoretical study is first described in this paper including the concept of the structural stability, the category of the overturning mechanisms and the preliminary model test. Then, using the same structural model, the computer structural analysis, in which software TDAPIII (Time-domain Dynamic Analysis Program in 3-dimension) is used, is explained in order to compare with the previous theoretical study. Consequently, the computer analysis confirms a good coincidence with the theoretical results. Further, by the computer analysis, the effect of the rotational stiffness of the foundation and the eigenvalue analysis to find the critical load are studied. In general, the computer analysis is a more practical tool to study the overturning mechanism than the theoretical analysis which is based on the equilibrium equations. The computer analysis would be possible to consider the material non-linearity of the foundation and 3-dimensional effect. In order to avoid this kind of overturning accident in the future, the results in this paper will give useful information to study further in details.
Attachment of the RNA degradosome to the bacterial inner cytoplasmic membrane prevents wasteful degradation of rRNA in ribosome assembly intermediates
Authors: Lydia Hadjeras , Marie Bouvier , Isabelle Canal , Leonora Poljak , Quentin Morin-Ogier , Carine Froment , Odile Burlet-Schlitz , Lina Hamouche , Laurence Girbal , Muriel Cocaign-Bousquet , Agamemnon J. Carpousis
In Research
RNA processing and degradation shape the transcriptome by generating stable molecules that are necessary for translation (rRNA and tRNA) and by facilitating the turnover of mRNA, which is necessary for the posttranscriptional control of gene expression. In bacteria and the plant chloroplast, RNA degradosomes are multienzyme complexes that process and degrade RNA. In many bacterial species, the endoribonuclease RNase E is the central component of the RNA degradosome. RNase E-based RNA degradosomes are inner membrane proteins in a large family of gram-negative bacteria (β- and γ-Proteobacteria). Until now, the reason for membrane localization was not understood. Here, we show that a mutant strain of Escherichia coli, in which the RNA degradosome is localized to the interior of the cell, has high levels of 20S and 40S particles that are defective intermediates in ribosome assembly. These particles have aberrant protein composition and contain rRNA precursors that have been cleaved by RNase E. After RNase E cleavage, rRNA fragments are degraded to nucleotides by exoribonucleases. In vitro, rRNA in intact ribosomes is resistant to RNase E cleavage, whereas protein-free rRNA is readily degraded. We conclude that RNA degradosomes in the nucleoid of the mutant strain interfere with cotranscriptional ribosome assembly. We propose that membrane-attached RNA degradosomes in wild-type cells control the quality of ribosome assembly after intermediates are released from the nucleoid. That is, the compact structure of mature ribosomes protects rRNA against cleavage by RNase E. Turnover of a proportion of intermediates in ribosome assembly explains slow growth of the mutant strain. Competition between mRNA and rRNA degradation could be the cause of slower mRNA degradation in the mutant strain. We conclude that attachment of the RNA degradosome to the bacterial inner cytoplasmic membrane prevents wasteful degradation of rRNA precursors, thus explaining the reason for conservation of membrane-attached RNA degradosomes throughout the β- and γ-Proteobacteria.
Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability
Authors: Christina M. Kelliher , Elizabeth-Lauren Stevenson , Jennifer J. Loros , Jay C. Dunlap
In Research
Compensation is a defining principle of a true circadian clock, where its approximately 24-hour period length is relatively unchanged across environmental conditions. Known compensation effectors directly regulate core clock factors to buffer the oscillator’s period length from variables in the environment. Temperature Compensation mechanisms have been experimentally addressed across circadian model systems, but much less is known about the related process of Nutritional Compensation, where circadian period length is maintained across physiologically relevant nutrient levels. Using the filamentous fungus Neurospora crassa, we performed a genetic screen under glucose and amino acid starvation conditions to identify new regulators of Nutritional Compensation. Our screen uncovered 16 novel mutants, and together with 4 mutants characterized in prior work, a model emerges where Nutritional Compensation of the fungal clock is achieved at the levels of transcription, chromatin regulation, and mRNA stability. However, eukaryotic circadian Nutritional Compensation is completely unstudied outside of Neurospora. To test for conservation in cultured human cells, we selected top hits from our fungal genetic screen, performed siRNA knockdown experiments of the mammalian orthologs, and characterized the cell lines with respect to compensation. We find that the wild-type mammalian clock is also compensated across a large range of external glucose concentrations, as observed in Neurospora, and that knocking down the mammalian orthologs of the Neurospora compensation-associated genes CPSF6 or SETD2 in human cells also results in nutrient-dependent period length changes. We conclude that, like Temperature Compensation, Nutritional Compensation is a conserved circadian process in fungal and mammalian clocks and that it may share common molecular determinants.
Impella 5.5 and venovenous extracorporeal membrane oxygenation as a bridge to ventricular assist device in cardiopulmonary failure
Authors: Austin Kluis , David Rawitscher , Aasim M. Afzal , J. Michael DiMaio , Timothy J. George
In Research
Venoarterial extracorporeal membrane oxygenation (ECMO) in the setting of combined cardiopulmonary failure provides full support of both cardiac and respiratory systems. However, it is difficult to isolate and evaluate pulmonary recovery independent of cardiac function on venoarterial ECMO. In this case report, we demonstrate the advantage of supporting a patient in cardiopulmonary failure with venovenous ECMO and the Impella 5.5 as a method to isolate organ dysfunction, wean off ECMO as respiratory function improves, and bridge to a left ventricular assist device with Impella 5.5 monotherapy.
Etiological Profile of Arthritis at the Teaching and Departmental Hospital Oueme-Plateau of Porto-Novo
Authors: Finangnon Armand Wanvoegbe , Ayaba Agossa , Kouessi Anthelme Agbodande , Adebayo Alassani , Edgard Tohounkpo , Yasmine Agonma , Alkinel Sokenou , Espoir Gandonou , Albert Dovonou , Angèle Azon Kouanou , Zavier Zomalheto
In Research
Introduction: Arthritis is common in rheumatology and has a large number of causes. Our goal in this study was to find out the etiological profile of arthritis in the rheumatology unit of the Teaching and Departmental Hospital Oueme-Plateau. Methods: This was a cross-sectional, descriptive, and analytical study, with retrospective collection, on the files of patients who consulted the rheumatology unit of the Teaching and Departmental Hospital Oueme-Plateau of Porto-Novo, from May 2015 to September 2021. All patients with arthritis were included. The data collected were recorded and analyzed using EPI INFO software version 7.2. Results: Out of 2416 records, 68 patients presented with arthritis, i.e., a hospital frequency of 2.8%. The mean age was 49.3 (± 16.9) years with extremes of 5 and 80 years. The majority were women (60.3%) with a sex ratio of 0.7. These patients were hypertensive in 42.6% of cases and diabetic in 10.3% of cases. The non-specific biological inflammatory syndrome was present in 75.5% of the 53 patients who underwent these explorations. Polyarthritis was present in most cases (52.9%), followed by monoarthritis (26.5%). The most recurrent etiological groups were autoimmune causes (38.8%), microcrystalline (35.8%), and infectious (14.9%). Rheumatoid arthritis was the most frequent cause (36.8%), followed by gout (25.0%), chondrocalcinosis (10.3%), tuberculosis (7.3%), septic arthritis (4.4%), and mixed spondyloarthritis (4.4%). Autoimmune causes were the first etiological group in women (52.5%) and microcrystalline causes were the first etiological group in men (59.3%), with a statistically significant difference (p = 0.010). Conclusion: The causes of arthritis in the Teaching and Departmental Hospital Oueme-Plateau are multiple, but are dominated by autoimmune, microcrystalline, and infectious causes.
Assessment of Cormic Index and Other Anthropometric Parameters of Young Adults with Sickle Cell Anaemia in Ile-Ife, Nigeria
Authors: Muritala Abiola Asafa , Rahaman Ayodele Bolarinwa , Samson Adeoye Oyewade , Oluwadare Ogunlade
In Research
This study assessed the effect of Haemoglobin SS (Hb SS) on cormic index and some other body anthropometric indices among students of Obafemi Awolowo University, Ile-Ife, Nigeria. A total of 100 young adults (18 – 40 years) participated in the study. They were classified into two groups; 50 cases (participants with Hb SS) and 50 control (participants with Hb AA) which were purposively selected after haemglobin typing using electrophoresis method. The cases and controls were age-and sex-matched. The weight, sitting and standing height were measured by using Seca stadiometer-model 216 following standard protocol. Cormic index (CI%) was calculated using sitting height x 100/ standing height while the body mass index (BMI) and body surface area were calculated using Keys and Monsteller formulae respectively. The data were analyzed using descriptive and inferential statistics and alpha value was set at p < 0.05. The mean values of weight in kg [54.39 ± 5.54 vs 60.48 ± 8.65 (t= -4.195, p < 0.001], body mass index in kg/m2 [19.58 ± 2.08 vs 21.48 ± 2.91 (t = 6.068; p < 0.001)], cormic index in % [44.71 ± 6.05 vs 50.03 ± 1.33 (t = -3.760; p < 0.001)], subischial leg length in cm [92.22 ± 10.76 vs 83.84 ± 4.41 (p < 0.001; t = 5.092)] and body surface area in m2 [1.59 ± 0.09 vs 1.68 ± 0.14 (p < 0.001, t = -3.798)] of cases were significantly different from those of controls respectively. In conclusion, this study showed that Hb SS is associated with lower weight, sitting height, body mass index, body surface area and cormic index but higher subischial leg length when compared with Hb AA.